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| Inflammation is the body’s first response to damage and infection. However, in many diseases, chronic and excessive inflammation exist and continue to cause pain and tissue damage preventing the body from healing. Luteolin has been shown to completely reverse the improper immune regulation of inflammation in the brain (microglia) evidenced by numerous medical publications. Recently it was shown that it is not only a single pathway that is affected by Luteolin, but over 50 inflammatory genes that turned off and over 100 healing genes that are turned on. No other drug or dietary compound known to man does this. |
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| CONCLUSIONS: |
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Our findings confirm the inhibitory effects of luteolin on pro-inflammatory cytokine expression in microglia. Moreover, our transcriptomic data suggest that this flavonoid is a potent modulator of microglial activation and affects several signaling pathways leading to a unique phenotype with anti-inflammatory, anti-oxidative, and neuroprotective characteristics. With the identification of several novel luteolin-regulated genes, our findings provide a molecular basis to understand the versatile effects of luteolin on microglial homeostasis. The data also suggest that luteolin could be a promising candidate to develop immuno-modulatory and neuroprotective therapies for the treatment of neurodegenerative disorders. |
| http://www.jneuroinflammation.com/content/pdf/1742-2094-7-3.pdf |
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| Luteolin is a potent anti-inflammatory compound that
inhibits the over-production and synthesis of TNF-alpha,
prostaglandins, leukotrienes, histamine, and interleukins,
thereby helping to prevent the negative effects of allergies,
inflammation, and overproduction of free radicals. |
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| THESE
STATEMENTS HAVE NOT BEEN EVALUATED BY THE FDA. THIS PRODUCT
IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE. |
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